c-kit-Positive cardiac progenitor cells: the heart of stemness.
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چکیده
CIRCULATION RESEARCH (ISSN 0009-7330) is published semimonthly except one issue per month in November and December and three issues per month in March and August by Lippincott Williams & Wilkins, at 12107 Insurance Way, Hagerstown, MD 21740. Business offices are located at Two Commerce Square, 2001 Market Street, Philadelphia, PA 19103. Production offices are located at 351 West Camden Street, Baltimore, MD 21201-2436. Individuals may subscribe for their personal use at the following annual rates: Domestic: $339 for members and $638 for nonmembers. International: $399 for members of an American Heart Association scientific council and $768 for nonmembers. Contact Lippincott Williams & Wilkins for single copy rates and subscription rates for medical professionals in training and for libraries, reading rooms, and other multiple-use institutions. Periodicals postage paid at Hagerstown, MD, and additional mailing offices. POSTMASTER: Send address changes to CIRCULATION RESEARCH, American Heart Association, Lippincott Williams & Wilkins, 12107 Insurance Way, Hagerstown, MD 21740. Online supplementary information Online movie files Available at http://circres .ahajournals .org Featured Article
منابع مشابه
Cardiac progenitor cells application in cardiovascular disease
Stem cells (SCs) have special potency to differentiate into different types of cells, especially cardiomyocytes. In order to demonstrate the therapeutic applications of these cells, various investigations are recently being developed. Cardiac progenitor cells are endogenous cardiac SCs that found to express tyrosine kinase receptors, c-Kit and other stemness features in adult heart, contributin...
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During embryogenesis, the mammalian heart develops from a primitive heart tube originating from two bilateral primary heart fields located in the lateral plate mesoderm. Cells belongings to the pre-cardiac mesoderm will differentiate into early cardiac progenitors, which express early transcription factors which are also common to the Isl-1 positive cardiac progenitor cells isolated from the de...
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BACKGROUND Laboratory large animal models are important for establishing the efficacy of stem cell therapies that may be translated into clinical use. The similarity of ovine and human cardiovascular systems provides an opportunity to use the sheep as a large animal model in which to optimize cell-based treatments for the heart. Recent clinical trials in humans using endogenous cardiovascular p...
متن کاملStem Cell Populations in the Heart and the Role of Isl1 Positive Cells
Cardiac progenitor cells are multipotent stem cells isolated from both embryonic and adult hearts in several species and are able to differentiate at least into smooth muscle cells, endothelial cells and cardiomyocytes. The embryonic origin of these cells has not yet been demonstrated, but it has been suggested that these cells may derive from the first and secondary heart fields and from the n...
متن کاملCardiac Explant-Derived Cells Are Regulated by Notch-Modulated Mesenchymal Transition
BACKGROUND Progenitor cell therapy is emerging as a novel treatment for heart failure. However the molecular mechanisms regulating the generation of cardiac progenitor cells is not fully understood. We hypothesized that cardiac progenitor cells are generated from cardiac explant via a process similar to epithelial to mesenchymal transition (EMT). METHODS/FINDINGS Explant-derived cells were ge...
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عنوان ژورنال:
- Circulation research
دوره 112 9 شماره
صفحات -
تاریخ انتشار 2013